[3] Thompson made his professional debut with the Arizona League Padres, tossing 12 innings of 2.25 ERA ball.

[7] He made his MLB debut on June 22, pitching one-third of an inning against the Los Angeles Dodgers, and earning a hold.

[8] On July 30, 2021, Thompson and Jordy Barley were traded to the Washington Nationals in exchange for Daniel Hudson.

In 2023, Thompson made 51 relief appearances for Washington, registering a 5.50 ERA with 44 strikeouts across 54.0 innings of work.

[14] On February 28, 2024, it was announced that Thompson would require Tommy John surgery, ending his season prematurely.