He read many books on these arguments that left him with numerous unanswered questions until he came upon Viaggio nel mondo del paranormale (Journey into the world of the paranormal) by Piero Angela.

[3] Polidoro corresponded with Randi and Angela by mail, where they planned a skeptical organization in Italy based on CSICOP's work in the United States.

[5] With a grant from Angela, Polidoro left for the United States and became Randi's only full-time apprentice in the art of paranormal investigation and psychic testing.

[3][6] After several years during which he helped Randi in his investigations, research, writings and lectures, Polidoro returned to Italy in 1990, where he co-founded CICAP with Piero Angela, and Lorenzo Montali.

[15] He has conducted historical investigations on famous cases and personalities of the past, including Eusapia Palladino, Margery and his childhood hero Houdini.

[14][16] In 2004, Polidoro's passion for magic led him to start the magazine Magia, devoted to the study of the history, science and psychology of conjuring.

[20] CICAP Fest is a series of events: talks and meetings with authors, scientists and intellectuals; workshops and spaces to engage the public with stimulating and fun activities.

Final Séance (2001) deals with the strange friendship between Houdini and Sir Arthur Conan Doyle, chronicling their friendly early exchanges through to their later quarrels over their opposing views of Spiritualism.

[30] He also undertook a touring theatrical performance mixing narrative, science, and art to highlight the man who was Leonardo, exploring how da Vinci came to be regarded as history's best-known polymath despite personal difficulties, societal resistance, and the limits of his own humanity.

[36][37] Each chapter of the book can be seen as a magic and science lesson that can teach the reader something about life: give it a try, without any expectations; cultivate your passions; always try; be humble and recognize your limits; change your perspective and seize the opportunities; criticize the claims, not the person; be selfless for the sake of being selfless; learn to make rational choices; don't disperse your attention; identify priorities; put order inside and outside yourself; persist in the face of difficulties and nourish absolute curiosity.

[44] Since 2017, Polidoro is a featured guest on Superquark, the most popular science television show in Italy, created and hosted by Piero Angela, where he discusses fake news, pseudoscience and how to develop rational thinking skills.

[48] Other Podacasts include: La prova: storia di una autopsia aliena (Proof: Story of an Alien Autopsy), Questa è scienza!

Other topics Polidoro covers in his YouTube videos include Harry Houdini, the September 11 attacks, the Moon landing conspiracy theories, chemtrails, the Hamer method, Paul McCartney, time travel, and pareidolia.

The character Mark Pollard of the Martin Mystere comic, The Great Houdini, created by Alfredo Castelli, was also inspired by Polidoro.

The club had approximately 100 members from around Italy and issued Help!, a fan magazine whose articles, in-depth reviews, and news were dedicated to the band.