[1] de los Santos began in the academy of Peñarol, prior to heading off to Almagro Baby Fútbol and Ferro Carril Salto of his hometown.
[3] After a further youth stint in the ranks of River Plate, de los Santos' senior career began with Danubio in 2013.
[1][4] He made his pro debut on 25 October in the Primera División, as he came off the bench with fourteen minutes left for Camilo Mayada.
[1] He would move clubs again one year later, though did manage to take his overall tally to eighty-three matches and six goals in the preceding months - winning the 2018 Superliga Colombiana in the process.
[1] On 18 July 2019, de los Santos secured a one-year loan move to Argentina with Vélez Sarsfield; with a future purchase option.