In the middle of the twentieth century the first phase of the cathedral's construction was completed at the end of the altar, the south nave and the lateral ones.

This church bears the same architectural style as the Église Saint-Joseph des Brotteaux [fr], in Lyon, France.

By January, 1898, the Roman catholic people of the city of Matehuala had asked Jose Maria Ignacio Montes de Oca y Obregón, bishop of the then-Diocese of San Luis Potosí, the demolition of a parish church that threatened collapse.

The Bishop asked his good friend president Porfirio Díaz to commission an architect, for building a new temple, being Adamo Boari the initiator of this important church.

Boari was based on the plans by Gaspard André, who had built the Saint-Joseph des Brotteaux church in Lyon.