The academic program is accredited by North Central Association of Colleges and Schools, and holds a Certificate of Recognition from the Illinois State Board of Education.

In addition, they added an outdoor football / soccer facility with a turf playing surface St. Boniface, St. Mary-Centralia, St. Bernard, St. Mary-Edwardsville, St. Rose, St. Felicitas, St. Stephen-Caseyville, St. Francis, St. Teresa-Marydale, St. George, St. Josephs, St. Paul, St. Dominics, St. Mary-Carlyle, St. Augustines, St. Cecilias, St. Marys-Trenton, St. Anthonys- Beckemeyer, and St. Damian.

[2] The school sponsors teams in basketball, bowling, cross country, golf, soccer, and track & field for both boys and girls.

The school sponsors teams in baseball and football for boys, while girls also compete in cheerleading, softball, and volleyball.

Mater Dei High School also hosts an annual Christmas Basketball Tournament beginning on December 26 every year since 1960.