The Mather Homestead is a historic house at 2 Mahl Avenue in Hartford, Connecticut.

The Mather Homestead is located in the Clay-Arsenal neighborhood on Hartford's north side, on the north side of Mahl Avenue just west of Main Street, the historic main road between downtown Hartford and Windsor.

Its main facade faces south, and is asymmetrically arranged, with three closely spaced windows at the center of the second floor and one at the left end.

The house originally had a Main Street address, which changed when Mahl Avenue was opened in that year.

After a period of domestic use, it was converted into a synagogue in 1926, and was acquired by what is now known as the Esp Masonic Lodge in 1954.