He joined Premier League club Huddersfield Town in July 2017 for a fee of £3.5 million, where he played until their relegation in 2019.

Born to a Danish mother and a Gambian father, Jørgensen moved to FC Copenhagen from neighbouring club B.93, where he had played in first-team matches even at the young age of 16.

[4] On 21 July 2007, Jørgensen strained the inner ligament in the left knee in a reserve team match – less than a month after he moved to the club.

[8] Only eight days after his first team debut, Jørgensen was thrown on pitch in the extra time of the UEFA Cup first round second leg at Parken Stadium against RC Lens, after captain Michael Gravgaard had received a red card.

He was substituted for Marcus Allbäck and played in the central defence together with Brede Hangeland, and they prevented any more goals for Lens, despite being down a man.

[11] Jørgensen was featured in an unofficial pre-season tournament, The Polish Masters, in July 2012 and scored his first goal for PSV in their game against S.L.

[12] On 7 July 2017, Huddersfield Town confirmed the signing of Jørgensen from FC Copenhagen for £3.5 million on a three-year contract.

[20][18][21] In July 2022, he joined the club's pre-season training camp in Germany, and on 22 August 2022 signed a new one-year contract with an option for an extra year, fulfilling both.

[24] On 17 August 2024, he made his debut for Anderlecht, immediately being placed into the starting XI in a 3-1 away win in a Belgian Pro League match against KV Mechelen, providing his first assist for the club.

In the 116th minute, he commit a professional foul in the penalty area to prevent Croatia from scoring a late winning goal, and was subsequently yellow carded.