[1] He grew up in Saleilles, a town in the suburbs of Perpignan, where he earned his scientific baccalaureate with honours, then a university degree in criminology, then became a lawyer.

When he was 25 he left the law profession to follow a career in comedy[2][3] He landed his first role in Un gars, une fille where he performed various voiceovers alongside Jean Dujardin and his wife Alexandra Lamy.

From September 2010 has been a part of the French television show Vivement dimanche prochain, presented by Michel Drucker.

From 2010 to 2011, he was also involved in Le Grand Direct des Médias with Jean-Marc Morandini shown on Europe 1.

[5] On 7 January 2015 Madénian did not go to work and escaped the shooting at the offices of the satirical weekly Charlie Hebdo.