Her artworks and paintings range from pencil portraits to embroidered quilts and have been exhibited in numerous art expositions throughout the world.

The oldest documented evidence of her early drawing skills is five portraits of Niendorf farmers, which she is said to have drawn at the age of twelve.

She received a two-year freelance position from Crown Princess Victoria in the Viktoria-Pensionat or Viktoria-Stift (retirement home in Erfurt) from the Lette-Verein and attended the association's arts and crafts drawing school.

At the same time, until 1 July 1877, she also took courses in the drawing school of the Vereins der Künstlerinnen und Kunstfreundinnen (Association of Berlin Women Artists).

Other painters with whom Mathilde Block took private lessons in Berlin over the years included Karl Gussow, Franz Skarbina, and Friedrich Geselschap.