The film features Sri Simha Koduri,[5] Satya, and Vennela Kishore reprising their roles from the first installment, with Faria Abdullah[6] and Sunil joining the cast.

Their colleague, Nidhi, believes in their innocence and helps them uncover clues, linking the case to hidden cameras and a bracelet belonging to Yuva, a famous actor.

When they confront Yuva, he admits to accidentally killing Riya, who was under the influence of a new drug 'Slave' provided by Akash, who used his club to exploit women.

Deepa confesses, revealing she sought revenge on Akash, who killed her husband during a failed arrest and exploited her daughter, blackmailing her.

In the post-credits scenes, Yuva confesses and takes the fall for all the events that have happened under the influence of Slave, and a mysterious figure puts Babu and Yesu to sleep, revealing himself to be Abhi.

Director Ritesh Rana, known for his unique comedic style and heavy use of meme culture, returned to helm the sequel.

The film's strengths include a hilarious first half, Satya's outstanding performance, Kaala Bhairava’s background music, and Ritesh Rana’s creative writing.

While the narrative gets jaded a bit in the latter part, Satya's hilarious performance makes the film a watchable fare for its clean entertainment.

"[11] Balakrishna Ganeshan of The News Minute gave it two-and-a-half out of five stars and wrote, "While Mathu Vadalara 2's absurd setting works, better writing would have made this film memorable, like its predecessor.

"[13] Nirupama Kodukula of Telangana Today wrote that "Overall, this movie moves along nicely, and it closes with a scene that suggests what comes next.

"[14] Sangeetha Devi Dundoo of The Hindu wrote, "Mathu Vadalara 2 is Satya's show all the way, with able support coming in from Simha Koduri, Faria Abdullah, Vennela Kishore, Ajay, Sunil and Raja Chembolu.