He joined with Edward Davis, Francois Grogniet, Pierre le Picard, and others hoping to intercept the Spanish treasure fleet off Panama.
They joined forces with Jean-Baptiste du Casse in early 1689, raiding off Cape Verde before returning to the Caribbean to attack Dutch colonies at Surinam and Berbice.
When war broke out against England they assaulted St. Christopher; while leading ground troops their ship was stolen by mutinous English crewmen, led by William Kidd and Robert Culliford.
[4] He captured a few small ships in late 1689, putting into Guadeloupe in early 1690 to repair and refit, where the impoverished locals were happy to trade for Desmarestz’ food and supplies.
[4] In August he captured a treasure-laden 24-gun Spanish frigate from Trinidad, keeping it for his own and renaming it Le Ballestrelle, and giving La Machine to Montauban.
After capturing English and Dutch vessels on the way he stopped in the Azores to resupply, where local French officials interceded to protect him from angry Dutchmen and Englishmen.