As a senior in 2019, he was recognized as the top defender in the nation with the Naismith Defensive Player of the Year and the Lefty Driesell Award.

[10] He attended Skyline High School for two years, then transferred to nearby Eastside Catholic,[10][11] where he was ranked a four-star recruit by Scout.com and three-star by ESPN,[12][13] and graduated in 2015.

Thybulle chose to attend the University of Washington in Seattle based on his relationship with Huskies coach Lorenzo Romar.

[8] As a sophomore in 2016–17, he averaged 10.5 points, 3.1 rebounds, and 2.1 steals,[14] but the Huskies won only two games in conference and were 9–22 in Romar's fifteenth season at Washington, and he was fired.

The former 22-year Syracuse assistant under Jim Boeheim sold him on the Orange's acclaimed 2–3 zone defense that he planned to install at Washington.

[19] Thybulle averaged a career-high 11.2 points per game, set a Huskies single-season record with 101 steals, and led Washington with a team-leading 49 blocks.

[19] In 2018–19, Thybulle had 17 points, six steals and five blocks in a 64–55 home win over Colorado to help the Huskies clinch a share of the Pac-12 regular season title.

They were coming off a second-round playoff loss to the eventual NBA champions, the Toronto Raptors, and were seeking someone who could immediately contribute to their goal of a championship.

[33] On October 23, he made his debut in NBA, coming off from bench in a 107–93 win over the Celtics with three points, a rebound, an assist, two steals and two blocks.

[35] On July 11, 2020, Thybulle started uploading a series of vlog style YouTube videos showcasing the 2020 NBA Bubble at the ESPN Wide World of Sports Complex in Orlando, Florida.

[40] He made his Trail Blazers debut on February 13, recording 14 points, six rebounds, two assists and three blocks in a 127–115 win over the Los Angeles Lakers.

[43] On February 3, 2021, Thybulle was named as part of the Australian Boomers squad for the delayed 2020 Tokyo Olympics, which began immediately after the 2021 NBA Finals.

"[47] Thybulle, who said that he was brought up in a "holistic household" with "Chinese medicine and naturopathic doctors" did say that he had received the first dose of the Pfizer vaccine but did not continue on for the following shot.