Matsudaira Nobutsuna (松平 信綱, December 19, 1596 – May 4, 1662) was a Japanese daimyō of the early Edo period, who ruled the Kawagoe Domain.
After the failure of Itakura Shigemasa to subdue the rebellion at Shimabara in 1637–38, Nobutsuna took command of the allied armies laying siege to Hara Castle, bringing the campaign to a successful conclusion.
In his later years, he joined senior Tokugawa officials such as Hoshina Masayuki in supporting the underaged 4th shōgun, Ietsuna.
Nobutsuna is portrayed as one of the two main villains in the manga series Shin Kozure Okami (New Lone Wolf and Cub).
To that end, he is willing to use any means no matter how despicable, even faking his own death and deliberately disfiguring himself physically in order to impersonate a powerful Satsuma nobleman.