He played in Major League Baseball (MLB) for the Florida Marlins, Houston Astros, Colorado Rockies, Baltimore Orioles, Arizona Diamondbacks, and Chicago White Sox.

The righty found himself back at Capital City midway through the season, where his numbers improved slightly, as he posted a 3–2 record with a 3.21 ERA and much-improved control, with a 1.61 BB/9.

Lindstrom went 2–5 with an ERA of 5.40 with eye-popping walk and home run rates of 6.75 BB/9 and 1.35 HR/9 in thirty-five games (ten starts, as the troubled righty was switched to bullpen duty midway through the season).

On November 20, 2006, Lindstrom and Henry Owens were traded to the Florida Marlins in exchange for Jason Vargas and Adam Bostick.

On December 9, 2009, Lindstrom was dealt to the Houston Astros for minor leaguers Robert Bono, Luis Bryan and a player to be named later, which became Rule 5 draft pick Jorge Jimenez, a third baseman selected from the Red Sox organization.

[3][4] After the 2010 season, Lindstrom was traded to the Colorado Rockies for two minor league pitchers: Wes Musick and Jonnathan Aristil.

He had early success, not giving up an earned run on the season until May 10, the day before he was placed on the disabled list with an injury to his right middle finger.