He was a standout at Gulfport High School, but he was a walk-on at Ole Miss, where scholarships were limited because of NCAA sanctions.

[6] After graduating from Ole Miss in 2000 with a Bachelor of Business Administration,[7] he took a job with Murray State University as an offensive line coach.

[8] Ole Miss fired Cutcliffe after the 2004 season, but new head coach Ed Orgeron retained Luke as part of his staff.

[9] At Duke, Luke was co-offensive coordinator with responsibility for the running game, while also coaching the offensive line.

[11] After a late season push to finish 6–6, Ole Miss removed the interim tag on November 26, 2017 and named Luke the 37th head football coach in school history.