On April 2, 2012, the Philadelphia Flyers of the National Hockey League signed Mangene as a free agent to a two-year entry-level contract, and he was assigned to begin his professional career with the Adirondack Phantoms of the AHL for the remaining games of the 2011–12 season.

[1] After three seasons in the Flyers minor league system, Mangene was traded to the New York Islanders along with a second and third-round draft pick for Andrew MacDonald on March 4, 2014.

[3] Following the end of the season, the Islanders did not make a qualifying offer to Mangene and he became an unrestricted agent on July 1, 2014.

[4] After establishing himself in the AHL in playing four seasons with the Texas Stars, Mangene left as a free agent following the 2017–18 season to sign a one-year contract with fellow AHL competitors, the Springfield Thunderbirds, affiliate of the Florida Panthers on July 3, 2018.

[5] Following his ninth season in the AHL, Mangene opted to pursue a career abroad, agreeing to a one-year contract with Austrian club, EC VSV of the Ice Hockey League on August 19, 2020.