Matthew Thomas Pagnozzi (born November 10, 1982) is an American former professional baseball catcher who played in Major League Baseball (MLB) for the St. Louis Cardinals, Colorado Rockies, Pittsburgh Pirates, Houston Astros, and Milwaukee Brewers.

He made his MLB league debut on September 29, 2009, appearing as a pinch hitter and drawing a walk.

The Pirates had previously tried to acquire Pagnozzi in June 2011, after catchers Ryan Doumit and Chris Snyder went down with injuries.

On December 4, 2012, Pagnozzi signed a minor league deal with the Atlanta Braves with an invitation to spring training.

He played the entire 2014 season with the Triple-A Nashville Sounds, before having his contract purchased by the Brewers on September 1.