[14] Walsh has campaigned against several hospitals, comparing the transgender healthcare they provide to child sexual abuse, genital mutilation, and rape.

[15][16] Walsh began his career as a talk radio co-host of The Matt and Crank Program at WZBH 93.5 FM in Georgetown, Delaware, from early 2010 to August 1, 2011.

[4][17] In 2012, he moved to Lexington, Kentucky, joining NewsRadio 630 WLAP[citation needed] and launching a website, The Matt Walsh Blog, in which he discussed various issues from a conservative point of view.

[20] He has appeared on Tucker Carlson Tonight,[7][21] The Ingraham Angle,[22] Fox and Friends,[23][24] Dr. Phil,[8] as well as the podcast The Joe Rogan Experience.

Walsh announced in April 2023 that the show was being moved to the Daily Wire website after his YouTube channel was demonetized for repeatedly misgendering transgender woman Dylan Mulvaney.

[33] St. Francis Xavier College Church, at Saint Louis University, canceled a speech by Walsh that it had planned to co-host with Young Americans for Freedom in December 2021.

[36] In 2023, the University of San Diego, a private Catholic educational institution, refused Walsh permission to speak on campus, for the reason that they regarded his opinions as "grossly offensive".

[38] Conservative news website TheBlaze called the book "an effort to push back against radical gender ideology which defies biological reality".

[40] LGBTQ Nation denounced the book, calling it "anti-transgender" and a mockery of transgender youth, while PinkNews referred to it as "hateful" and "transphobic".

Detractors, such as AJ Erkert of Science-Based Medicine and Erin Rook of LGBTQ Nation, denounced the film as "propaganda", "transphobic lies", and "science denying".

[55] Eventbrite banned screenings of the documentary due to the service not permitting content that promotes "hate, violence, or harassment towards others and/or oneself".

[56] In February 2022, Eli Erlick, a transgender activist, alleged that Walsh had invited dozens of people to participate in the documentary under false pretenses.

[69] Walsh starred in, co-wrote, and co-produced the documentary film Am I Racist?, released on September 13, 2024, which lampooned the diversity, equity, and inclusion (DEI) movement.

[94] Walsh has argued that ozone depletion and acid rain were never serious problems, in tweets that Ars Technica described as "willfully ignoring some very well-documented history".

Walsh's commentary was mocked on CNN by digital senior entertainment writer Lisa France, who said "racism is real, unfortunately, and people get so offended".

Other commentators quoted by PinkNews argued that Walsh was wrong, attributing the increase to different factors, including an easing of social stigmas among younger people.

[106] The New York Times columnist Michelle Goldberg argued that Walsh's commentary, as well as that of other right-wing commentators, have caused an increase of anti-LGBT violence and sentiment in the United States.

[107] The Southern Poverty Law Center (SPLC) described Walsh as one of the "peddlers of fear and disinformation about LGBTQ people" in the wake of the Club Q mass shooting in November 2022.

[110][111] He also rhetorically asked those on the left who felt that "the drag queen-child combination" would lead to "violent backlash" from right-wingers, "if it's causing this much chaos and violence, why do you insist on continuing to do it?

"[112][113] Jeet Heer from The Nation described Walsh's comments, along with those of a few other right-wing figures, as "implicitly a threat," saying, "The right is trying to create a new lynching culture, with LGBTQ people as the target.

"[114] Walsh has repeatedly opposed the transgender community[13] and "gender ideology",[115] notably with his children's book Johnny the Walrus,[13] his documentary What Is a Woman?,[58] and campaigns involving hospitals and schools.

"[115] Walsh has compared giving hormone treatments and gender-affirming surgery for transgender youth to "being sexually violated in a way that is just as depraved or damaging as molestation or rape".

In May 2021, Walsh called doctors who perform gender-affirming surgeries for transgender youth "Nazi scientist-evil", "pedophiles", and "plastic surgeons basically acting like Leatherface from The Texas Chain Saw Massacre".

[115] Walsh rented an apartment in Virginia for one day in 2021 to qualify to speak out against the Loudoun County School Board for allowing transgender students the use of restrooms matching their gender identity.

[81] In November 2022, Walsh was challenged as a guest on the podcast The Joe Rogan Experience for suggesting that "maybe millions of kids" had been put onto puberty blockers.

[119][independent source needed] Following Walsh's statements Erlick reported harassment on social media, including messages with anti-LGBT slurs and threats of physical violence.

Erlick accused Walsh of "profiting from the moral panic over transness", "attacking free speech itself", and stochastic terrorism, which is incitement of violence against a target through mass media with plausible deniability.

[9][79][121] In September 2022, Walsh made accusations against another hospital, Vanderbilt University Medical Center (VUMC), and its transgender clinic in Nashville, Tennessee.

After South Dakota Governor Kristi Noem permitted businesses to require a COVID-19 vaccine for their employees, Walsh criticized her by writing that she was only considered a frontrunner for the 2024 United States presidential election because of her physical attractiveness.

Ocasio-Cortez responded to the criticism by saying, "My abuela (Spanish: "grandmother") is okay ... but instead of only caring for mine & letting others suffer, I'm calling attention to the systemic injustices you seem totally fine [with] in having a US colony.