On April 5, 2015, he was traded to the Atlanta Braves, along with Carlos Quentin, Cameron Maybin, Jordan Paroubeck, and the 41st overall draft pick, in exchange for Craig Kimbrel and Melvin Upton, Jr.[10] He was then sent to Triple-A Gwinnett.

Fellow rookie pitchers Manny Banuelos and Mike Foltynewicz suffered injuries later that month, and Wisler was reinserted into the starting rotation.

[17] On April 17, Wisler recorded his first major league save, helping the Braves secure a sweep of the Miami Marlins.

[21] He pitched well against the Arizona Diamondbacks and San Diego Padres, and left the latter start with a strained oblique.

[15][22] In the offseason, Wisler pitched two games in the Dominican Winter League for Tigres del Licey.

On July 30, 2018, the Braves traded Wisler, Lucas Sims, and Preston Tucker to the Cincinnati Reds in exchange for Adam Duvall.

[35][36] On June 11, 2021, Wisler was traded to the Tampa Bay Rays in exchange for minor league pitcher Michael Plassmeyer.

[37][38] On July 7, Wisler combined with Collin McHugh, Josh Fleming, Diego Castillo, and Peter Fairbanks to no–hit the Cleveland Indians.

[39] Wisler appeared in 27 games for Tampa Bay down the stretch, pitching to a 2–3 record and 2.15 ERA with 36 strikeouts in 29.1 innings of work.

He posted a 3–3 record and 2.86 ERA with 34 strikeouts and 14 walks, before missing significant time from July to September with a neck injury.

[45][46] In 39 appearances for the Triple–A Toledo Mud Hens, he posted a 5–2 record and 4.40 ERA with 53 strikeouts and 2 saves in 47.0 innings of work.

[47] On August 12, 2023, Wisler signed a minor league contract with the Toronto Blue Jays.

However, during his rookie year with the Braves, he began pairing his fastball with a slider instead, throwing his changeup on only 8.5% of pitches.