The Matteo Pellicone Ranking Series 2021 was a wrestling event held in Ostia, Rome, Italy between 4 and 7 of March 2021.

[1] The first United World Wrestling Ranking Series event of the year, it featured multiple World and Olympic Champions, Pan-American Champions, European Champions, Asian Champions and NCAA Champions.

[2] March 6–7 March 4–5 March 4–5