[3] After compiling a record of 4–2–1 (3 KOs), he defeated Carlo De Novellis via unanimous decision (UD) to capture the vacant Italian interim middleweight title on 12 July 2008, in Sequals.

[4] Signani challenged for the full Italian title three months later, losing via majority decision (MD) against reigning champion Gaetano Nespro on 31 October in Savignano sul Rubicone.

[10] Signani bounced back with three victories before capturing the Italian title for a second time, defeating Stefano Loriga by UD on 27 July 2013, in Castel Volturno, with the judges' scorecards reading 97–89, 97–92 and 95–94.

Following an examination, the doctor determined the cut was too severe to allow the fight to continue, bringing a premature end to the contest via technical decision to leave the European Union title vacant.

[15] He scored a TKO victory against Alexander Bojic in a non-title fight in February 2016,[16] before facing Emanuele Blandamura for the vacant European middleweight title on 3 December at the Palasport in Colleferro.

[24] Signani lost his title to Tyler Denny at Wolverhampton Civic Hall in England on 18 November 2023, via technical knockout after failing to answer the bell at the start of the eighth round.