Brady defeated previous district attorney Charles Fickert, who was responsible for the conviction of Tom Mooney and Warren Billings in the Preparedness Day bombing.

In 1935, he empaneled a grand jury and hired private investigator Edwin Atherton to report on police corruption in the San Francisco Police Department.

Brady presided over numerous high-profile cases in the 1920s and 1930s, including the three Fatty Arbuckle murder trials, and the arrest and roundup of Communists.

during the infamous sterilization plot charged by Ann Cooper Hewitt, 21-year-old heiress, and daughter of Peter Cooper Hewitt, against her mother, Marion Jeanne Andrews, accused of sterilizing her daughter, Ann, to thwart an inheritance dependent on the young woman having children, in a climate of California Eugenics law, and aided by Dr. Tilton E Tillman and Samuel G.

[1][2][3][4][5][6][7][8][9][10][11][12][13] He was defeated for reelection by Pat Brown in 1943, which was the second time the two had competed for the office.