Matthew Ho was born on 3 August 1988 in Hong Kong and attended St. Stephen's College in Stanley, Hong Kong until the age of 14, Form 3, when he and his family immigrated to San Francisco, California.

Half a year after his graduation, Ho returned to Hong Kong and became a DJ for the internet radio station, 9DTV.

[2] In 2012, he graduated from TVB's 26th artiste training class, and officially signed with the company.

[4] In 2016, Ho garnered more attention with his performance in the legal drama Law dis-Order.

At the 2017 TVB Anniversary Awards, he won the Most Popular Onscreen Partnership award with Edwin Siu and Raymond Cho with their collaboration in the drama A General, a Scholar and a Eunuch.