Knight endured a long list of injuries during his tenure with the Wildcats, having struggled with calf, shoulder, ankle and toe complaints, as well as suffering a number of concussion-related incidents.

He was a talented footballer growing up, following in the steps of his father, Scott, who played five games for Collingwood in the VFL in 1984 before carving out an accomplished career in Tasmania.

[8] He subsequently went on to play for the Australian junior national team at the 2003 FIBA Under-19 World Championship, where he won a gold medal.

[9] On 10 June 2003, Knight and future Perth Wildcats teammate Damian Martin signed National Letters of Intent to join the Loyola Marymount University men's basketball program.

[10] Knight was slowed by ankle surgery following the 2003 FIBA World Championship and subsequently missed the first six games of the 2003–04 season.

[6][11] As a sophomore in 2004–05, Knight proved to be the go-to-guy for the Lions all season, and for his efforts, he earned All-West Coast Conference honorable mention honours.

[6] As a junior in 2005–06, Knight was a Player of the Year candidate in the West Coast Conference and earned first-team All-WCC honours.

He scored in double figures in every WCC game and had a career-best 32 points and 18 rebounds against Long Beach State on 30 November 2006.

Their season ended with a loss to the University of Portland at the Chiles Center in the first round of the West Coast Conference Championships.

After team owner Greg Evans was served a default notice, all players were asked to take a 50 per cent pay cut.

[28] He was lured to the club by his Sydney Spirit comrades, Damian Martin and Rob Beveridge, with the pair coming off an NBL championship with the Wildcats in 2009–10.

[29] Upon moving to Perth, Knight joined the Rockingham Flames of the State Basketball League (SBL) and had a three-game stint with the club in mid-July.

[30][31] Knight's debut season for the Wildcats began positively before a left calf injury suffered on 12 December 2010 against the Melbourne Tigers ruled him out for two months.

After defeating the Gold Coast Blaze 2–1 in the semi-finals, the Wildcats moved on to the Grand Final series where they faced the New Zealand Breakers.

[35] Knight embraced the responsibility that came with being the team's primary focus under the basket, and excelled in the Wildcats' season-opening win over the New Zealand Breakers, earning the NBL's Player of the Week award for a 20-point, nine-rebound effort.

[38] The Wildcats returned to the Grand Final in 2014 and defeated the Adelaide 36ers 2–1 to win the NBL championship as Knight claimed his first title.

[45] On 19 April 2016, Knight re-signed with the Wildcats on a two-year deal,[46] a month after undergoing shoulder stabilisation surgery on his left arm.

[48] However, the joint responded well to rehab and after a week of full training with the team, Wildcats medical staff gave him the all-clear on 20 October 2016.

[52] The win propelled the Wildcats into their 31st consecutive NBL Finals appearance, as they finished the regular season in third place with a 15–13 record.

[53] Knight helped the Wildcats win through to another NBL Grand Final after sweeping the second-seeded Cairns Taipans in the semi-finals.

In Game 1 of the best-of-five grand final series, Knight scored 18 points to help lift the Wildcats to an 89–77 win over the Illawarra Hawks.

[54] In Game 2 of the series, Knight had to be helped off the court after seemingly innocuous contact from teammate Casey Prather early in the third quarter.

Knight sustained two head knocks over the last month of the 2016–17 NBL season, both of which resulted in him being unable to complete the game and missing a subsequent contest.

[58][59] Wildcats managing director Nick Marvin acknowledged that the club would consult with Knight during the 2017 off-season, with six concussion-related incidents in six years raising concerns over his long-term health.

Scans revealed a small fracture and ligament damage in his right thumb, with Wildcats medical staff opting to take a non-surgical approach to repairing the injury.

[70] In 2013, Knight considered a switch to Australian Rules football in order to follow in his father's footsteps after attracting interest from WAFL club West Perth.