Noted for possessing a level of agility and endurance unusual for a player of his size, Kreuzer was widely expected to be selected early in the 2007 AFL Draft.

He earned a NAB Rising Star nomination in his ninth game (against Port Adelaide), after moving into the forward-line in the final quarter and scoring three goals, which helped Carlton overcome a 30-point deficit in wet conditions; he would ultimately poll eleven votes to finish fourth for the award.

Kreuzer played all twenty-three games in his second season, again sharing ruck duties and spending some time in the forward-line, again scoring thirteen goals.

In Round 13, 2010, after 56 consecutive games from debut, Kreuzer ruptured his anterior cruciate ligament after landing awkwardly in a marking contest.

[7] At the end of the 2018 season, Kreuzer had relinquished his position in the leadership group, along with Alex Silvagni and Lachlan Plowman.

[8] In the opening round of the 2020 AFL season against Richmond, Kreuzer suffered a foot injury which initially ruled him out for three to four months, but he did not play again and announced his retirement, with immediate effect, on 10 September 2020.