[21] The Whipping Man is set in Richmond, Virginia in the immediate aftermath of the American Civil War and concerns two recently freed slaves encountering their former master.

In his The New York Times review Charles Isherwood called the play "emotionally potent, almost surreal in the layers of meaning it conjures.

The play, featuring a majority Latin cast, concerns a theatrical family living in Manhattan in 1959, as West Side Story captured the zeitgeist.

The story follows Jonathan, a young gay New Yorker, who spends increasingly more time holed up in his Astoria apartment following a violent attack that has left him afraid to go out into the world.

He is befriended by his new upstairs neighbor, Claire, a Holly Golightly-like character who, despite her active social life, is just as afraid and lonely as Jonathan.

"[30] The Legend of Georgia McBride debuted at Denver Center for the Performing Arts[31] in 2014,[32] and premiered Off-Broadway at the Lucille Lortel Theatre[33] in 2015.

[40] Set in New York three decades after the height of the AIDS epidemic, The Inheritance wrestles with what it means to be a gay man today, exploring relationships and connections across age and social class and asking what one generation's responsibilities may be to the next.

[42] In June 2020, in honor of the 50th anniversary of the first LGBTQ Pride parade, Queerty named him among the fifty heroes "leading the nation toward equality, acceptance, and dignity for all people".

The musical is a radical re-imagining of the beloved film for a modern audience, in which the character of Daphne (in a Tony Winning Performance[46] by J Harrison Ghee) begins to reevaluate their gender identity.

Set in Chicago when Prohibition has everyone thirsty for a little excitement, Some Like It Hot is the rollicking story of two musicians forced to flee the Windy City after witnessing a mob hit.

[47] López made his directorial debut in summer 2023 with the film adaptation of the LGBTQ+ romantic comedy Red, White & Royal Blue for Amazon Studios.

[49] The film depicts a developing love affair between the son of the president of the United States (Taylor Zakhar Perez) and a British prince (Nicholas Galitzine).

López is also working on a reimagining of the iconic 1992 Whitney Houston box office hit, The Bodyguard, for Warner Bros,[50] as well as a feature film adaptation of the novel Leading Men for Searchlight Pictures, which centers on Tennessee Williams and his longtime partner Frank Merlo.