Born in Elte, North Rhine-Westphalia, Weischer studied painting from 1995 to 2001 and received his MA in 2003 from Hochschule für Grafik und Buchkunst (HGB) in Leipzig.
In 2002, he was a co-founder of the artist-initiated gallery LIGA in Berlin that was run by eleven former HGB students, among them Christoph Ruckhäberle, Tim Eitel, David Schnell and Tilo Baumgärtel.
Until 2006, his paintings depicted deserted interiors like stage settings that are infused with abstract elements.
Since 2001, his work has been exhibited worldwide, e.g. in London (2003), Miami (2004), at the Venice Biennale, the Cleveland Museum of Art, in Chungnam, Korea (2005), The Hague, Málaga (2008), Ponce, Puerto Rico (2011), Hong Kong (2015) and Amsterdam (2017).
Among the public and private collections holding works by Matthias Weischer are the Museum of Contemporary Art, Los Angeles, Gemeentemuseum Den Haag, The Hague, Arken Museum of Modern Art, Denmark, Arario Collection, Corea, Museum der bildenden Künste, Leipzig, Rubel Family Collection, Miami and Susan and Michael Hort, New York.