Binotto was part of the team during the successful early 2000s, when Michael Schumacher secured five consecutive Formula One World Championships.

In 2013, Binotto became Head of the Engine Department, before becoming chief technical officer (CTO) of Ferrari in July 2016, replacing James Allison.

[4] During Binotto's two years as CTO, Ferrari once more competed for regular race wins.

[6] In 2023, Binotto worked as a consultant for TEXA (Tecnologie Elettroniche X Automotive) in Treviso.

[7] On 1 August 2024, Binotto was announced as the replacement for Andreas Seidl and Oliver Hoffman as COO and CTO of Sauber Motorsport.