[7] Samuelsson made his NHL debut with the Sabres on April 18, 2021, in a 4–2 win against the Pittsburgh Penguins.

[10][11] Samuelsson scored his first NHL goal on November 30, in a 5–4 shootout win over the Detroit Red Wings.

[12] On February 4, 2024, Samuelsson was ruled out for the rest of the 2023–24 season due to an injury sustained in a January 23 game against the Anaheim Ducks.

[16][17] Samuelsson's father, Kjell, played 14 seasons as an NHL defenseman for the Pittsburgh Penguins, Philadelphia Flyers, New York Rangers and Tampa Bay Lightning.

[20] Samuelsson grew up modeling his game after that of longtime NHL defensemen Mattias Ekholm[2] and Victor Hedman.