She is known for her work as the co-creator, show runner, and executive producer of Marvel's Agents of S.H.I.E.L.D., which aired on the ABC television network for 7 seasons from 2013 to 2020.

[1][2] Tancharoen has worked as an actor, writer, production assistant, showrunner, and executive producer in television and film.

She began working as a production assistant under producer Mark Tinker on NYPD Blue and William M. Finkelstein on Brooklyn South.

[11][12] In addition to her writing and production credits, Tancharoen has appeared on screen or contributed voice talent in episodes of Dollhouse, Dr. Horrible's Sing-Along Blog, and Joss Whedon's 2011 adaptation of Shakespeare's Much Ado About Nothing.

According to her Twitter posts, she performed backing vocals and danced in the video for The Guild parody song "(Do You Wanna Date My) Avatar" released on August 17, 2009.

She began writing during her time at Occidental and authored two plays which earned the school's Argonaut & Moore literary award.

Her early symptoms of fatigue, joint pain, and a butterfly rash intensified as she aged resulting in periodic episodes in which the autoimmune disease attacks her organs and central nervous system.

"[20] Her friends and family formed Club Mo to raise money for the Walk for Lupus Now event in Los Angeles in 2011.