[1][3] He served as deputy house speaker until 28 April 2013 when he was appointed minister of infrastructure and transport in the Letta cabinet.

[7][8] Lupi continued to serve as the minister of infrastructure and transport in the cabinet formed by Matteo Renzi in February 2014.

[9] On 19 March 2015, Lupi announced that he would step down as minister the following day due to a scandal involving public works on infrastructure in which his name was cited several times.

[3] In the Letta cabinet, Lupi was one of two members of the Catholic movement Communion and Liberation.

[12] He is a strong supporter of the TAV project that would connect Italy and France via high-speed rail.