Mauro Gambetti was born in Castel San Pietro Terme, Italy, on 27 October 1965.

He earned a degree in mechanical engineering from the University of Bologna.

[1] On 25 October 2020, Pope Francis announced he would raise him to the rank of cardinal at a consistory scheduled for 28 November 2020.

[5] His term as General Custos was due to expire in 2021[6] but he was instead succeeded in that position on 12 November by Father Marco Moroni.

[8][9] At that consistory, Pope Francis made him cardinal deacon of Santissimo Nome di Maria al Foro Traiano.