Mauro Picone (2 May 1885 – 11 April 1977) was an Italian mathematician.

He is known for the Picone identity, the Sturm-Picone comparison theorem and being the founder of the Istituto per le Applicazioni del Calcolo, presently named after him, the first applied mathematics institute ever founded.

[1] He was also an outstanding teacher of mathematical analysis: some of the best Italian mathematicians were among his pupils.

Attraverso le sue ricerche di analisi matematica, Mauro Picone ha contribuito notevolmente allo sviluppo della matematica del nostro secolo.

Egli è stato inoltre un pioniere delle matematiche applicate.