Mauzac (French pronunciation: [mozak]; Occitan: Mausac) is a commune in the Haute-Garonne department in southwestern France.

The village lies on the middle banks of the Garonne river.

The commune is bordered by four other communes: Le Fauga to the north, Beaumont-sur-Lèze to the east, Montaut to the south, and finally by Noé to the west.

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