A member of the African National Congress, Lerule-Ramakhanya is a former mayor of the Vhembe District Municipality.
In March 2020, Lerule-Ramakhanya was appointed as the Member of the Executive Council (MEC) for Transport and Community Safety.
She took office as mayor of the Makhado Local Municipality on 1 December 2008, succeeding Glory Mashaba.
[4] She succeeded Florence Radzilani, who resigned following her involvement in the VBS Mutual Bank controversy.
[6] On 23 March 2020, premier Stanley Mathabatha appointed Lerule-Ramakhanya as the Member of the Executive Council responsible for the provincial Department of Transport and Community Safety, succeeding Dickson Masemola.