[4] Burkholder attended Harvard University as a member of the Class of 2021, studying biology, but dropped out after his freshman year to pursue acting full-time.

In addition, he played Billy in one episode of The Suite Life of Zack & Cody on Disney Channel and was the voice of Samsquatch in Random!

He also appeared in the television series In Treatment and Love for Rent and played the role of Duncan in the episode of Grey's Anatomy, "Brave New World".

[11] For Burkholder's role as Max Braverman on Parenthood, executive producer Jason Katims said consultant Wayne Tashjian, a behavioral psychologist, looked at the script and met with Burkholder and his mother about those scenes involving the character of Max.

[12] In 2025, Burkholder was announced as a guest performer on the second season of the panel show Smartypants, streaming on Dropout.