He played college football for the Georgia Bulldogs, earning consensus All-American honors in 2005.

He was a key starter of the Bulldogs team that defeated the LSU Tigers by a score of 34–14 to win the 2005 SEC Championship Game.

On September 23, 2007, Jean-Gilles made his regular season debut for the Eagles, subbing in for an injured Shawn Andrews.

[4] Jean-Gilles' 2008 season was cut short on Thanksgiving night against the Arizona Cardinals when he fractured his ankle and was placed on injured reserve.

On August 2, 2011, Jean-Gilles signed a one-year contract with the Cincinnati Bengals, but was released on September 3.

Jean-Gilles signed with the Lincoln Haymakers of the Champions Professional Indoor Football League on August 27, 2013.