Maxey-sur-Meuse (French pronunciation: [maksɛ syʁ møz], literally Maxey on Meuse) is a commune in the Vosges department in Grand Est in northeastern France.

Confusingly, the similarly named commune of Maxey-sur-Vaise in the adjacent Meuse département is only 10 kilometres (6 mi) away, to the north.

Neufchâteau is 13 kilometres (8 mi) away to the south.

Maxey is across the river Meuse from a road junction where traffic bound for Commercy continues in a northerly direction (RD964) while traffic for Bar-le-Duc turns to the north-west (RD966) The (here relatively small) river Meuse flows through Maxey where it is joined by the waters from the Vair and three smaller streams, the Roises, the Vau and the Blanchonrupt.

The presence of all these water courses makes the village popular with anglers.