The maxillary second premolar is one of two teeth located in the upper maxilar, laterally (away from the midline of the face) from both the maxillary first premolars of the mouth but mesial (toward the midline of the face) from both maxillary first molars.

The function of this premolar is similar to that of first molars in regard to grinding being the principal action during mastication, commonly known as chewing.

In the universal system of notation, the permanent maxillary premolars are designated by a number.

In the Palmer notation, a number is used in conjunction with a symbol designating in which quadrant the tooth is found.

The international notation has a different numbering system than the previous two, and the right permanent maxillary second premolar is known as "15", and the left one is known as "25".