Maxixcatl[1] was the tlatoani (ruler) of the Nahua altepetl (city-state) of Ocotelolco, one of the four towns that formed the state of Tlaxcallan.

He was one of the main signers of the alliance with Hernán Cortés during the Spanish conquest of the Aztec Empire.

Maxixcatzin was instrumental in forming the alliance between Tlaxcallan and the Spanish force of Hernán Cortés against the Aztecs.

[2]: 140–188  He gave his daughter Zicuetzin, baptized as Luisa, to Juan Velazquez de Leon, both of whom were killed on La Noche Triste.

[2]: 307 Maxixcatl died in the smallpox epidemic which decimated the indigenous population of central Mexico in 1520.