[citation needed] Mayamruga revolves around five middle-class women, Malavika, Shree Lakshmi, Brunda, Dakshayini and Vidhya, who strive to maintain a balance between their personal and principled living.

Malavika is a middle class born woman rights activist who dreams of an ideal society with equality and liberated women.

When she finds an ideal man in Krishna Prasada who is her professor, she marries him by opposing her family consisting of Father Narayana Murthy, elder brothers Shreedhara and Ranganatha, younger sister Vidhya.

Moreover, with Malavika's hostility towards her in-laws, her husband Krishna Prasada is attracted to his childhood friend Sharmila, also an only daughter of rich financier financing Mohana Murthy's business.

[4] Brunda is a middle-class girl who intends to find a job to support her aging father Soorappa, whose street watch repair business is not doing well and whose earnings are insufficient to support the large joint family in which she lives, comprising her mother, jobless elder brother Hari, younger brother, younger sister Harini and distant relative Mukunda.

Brunda's father also wants to get her married and most of her arranged marriage proposals are cancelled either because she is jobless or because of her sister Harini, who goes missing from her house, who is revealed to be kidnapped, captivated and raped by her own professor.

This makes him to acquire a garment business by false encouragement of his frined Rajendra, which gets him into lots of financial burden due to lack of experience.

Vidhya is a polio handicapped girl who is younger sister of Malavika, she lives with her father Narayana Murthy and elder brother Shreedhara.

Shreedhara on the other hand is angry young man who tries to be journalist but have his own ups and downs due to his hot headed character and lack of education and improper upbringing by his father.

Meanwhile, she gets honey trapped by a jail return goon forgery Rajeeva, he makes Malavika persuade her family to consent their only house to his name in leu of marrying handicapped Vidhya.