The series stars Alexandra Daddario as Rowan Fielding, Harry Hamlin as Cortland Mayfair, Tongayi Chirisa as Ciprien Grieve, and Jack Huston as Lasher.

[8] In May 2020, it was announced that AMC had acquired the rights to The Vampire Chronicles and Lives of the Mayfair Witches for developing film and television projects.

Rice said, "It's always been my dream to see the worlds of my two biggest series united under a single roof so that filmmakers could explore the expansive and interconnected universe of my vampires and witches.

"[11] Johnson added, "My good fortune as an executive producer of Anne Rice's Interview with the Vampire has now been more than doubled with what Esta Spalding and Michelle Ashford are imagining with The Mayfair Witches.

"[11] In January 2023, at AMC's TCA press tour, Johnson announced a crossover between Mayfair Witches and Interview with the Vampire is in discussions.

[7][16] In May 2022, Jack Huston was cast as Lasher, described as one of Rice's "most mysterious and sensual characters—a powerful, shape-shifting entity who has been bound to the Mayfair witches for hundreds of years.

Ted Levine was cast in a recurring guest starring role as Julien Mayfair, Cortland and Carlotta's father, and "a master manipulator".

The website's critics consensus reads, "Mayfair Witches has competent gloss and a likable lead in Alexandra Daddario, but this brew is made up of too many derivative elements to conjure a compelling spell of its own.