Mayflower was the victorious U.S. defender of the sixth America's Cup in 1886 against Scottish challenger Galatea.

The sloop Mayflower was the second America's Cup defender designed by Edward "Ned" Burgess, built by George Lawley & Son and launched in 1886 for owner General Charles J. Paine of Boston.

[3] In 1905 Lady Eva Barker bought the vessel and outfitted it with an engine.

She chartered it to adventurer Guy Hamilton Scull in 1908 on an expedition seeking the treasure of a sunk Spanish galleon off Jamaica.

The Mayflower was sunk itself off Cuba in a hurricane during this expedition, and the crew was rescued by passing steamers.