Her stage name is derived from Manimekhala, a Buddhist goddess.

During her second year in college, she was encouraged by faculty to sing a cover of Nwe Yin Win's "Love Is..." (အချစ်ဆိုတာ) at the Yangon City Hall's Thingyan pandal.

Myint Lwin was persuaded by her performance to produce music on her behalf.

Following the success of her music career after 1980, famous composers like Kaiser, Naing Myanmar, and Win Min Htwe composed music for her.

Maykhala's hits include "Leave Now" (ပြန်ပေတော့), "Loving That Much" (အဲ့သလောက်တောင်ချစ်ရသည်), and "Once at University" (တစ်ခါက တက္ကသိုလ်).