Mayo is a census-designated place (CDP) in Spartanburg County, South Carolina, United States.

[6] According to the United States Census Bureau, the CDP has a total area of 3.1 square miles (8.0 km2), all land.

As of the census[4] of 2000, there were 1,842 people, 719 households, and 532 families residing in the CDP.

There were 773 housing units at an average density of 247.9 per square mile (95.7/km2).

22.4% of all households were made up of individuals, and 8.3% had someone living alone who was 65 years of age or older.