Mayo Clinic Proceedings is a monthly peer-reviewed medical journal published by Elsevier and sponsored by the Mayo Clinic.

It covers the field of general internal medicine.

The journal was established in 1926 as the Proceedings of the Staff Meetings of the Mayo Clinic and obtained its current name in 1964.

[1] Initially, its website consisted of simple lists of tables of content.

In addition to the journal content, it contains extra features such as Medical Images, Residents Clinics, Art at Mayo, and Stamp Vignettes on Medical Science, as well as author interviews and monthly issue summaries.