It is notable for being constructed in an almost perfect circle aside from a few appendages, and for housing the Rochester Planetarium.

The current principal of Mayo High School is Troy Prigge.

Mayo High School was built in 1966 in the southeastern section of Rochester, Minnesota.

It has teams in speech, chess, classic debate, theatre, mock trial, football, tennis, swimming, cross country, soccer, lacrosse, softball, baseball, rowing, basketball, golf, hockey, volleyball, track and field, Science Olympiad, FIRST Robotics Competition team, Math League, and Knowledge Bowl.

[7] Mayo High School acquired the removable NFL football turf from the Minnesota Vikings after the demolition of the Metrodome in 2014.