She was the daughter of Charles Barry, a humorist and founding member of the comedy show Radio Rochela, and Ligia Lezama, a teleplay writer and actress.

Other notable roles include Bienvenida Esperanza (1983), Marta y Javier (1983), and La mujer prohibida (1991).

[1][2] Lezama developed a femme fatale image with early roles,[citation needed] notably as Carmen in Román Chalbaud's Carmen la que contaba 16 años (1978) and as Manon Lescaut in Chalbaud’s adaptation of Manón (1986).

Following a hiatus to focus on her family, Lezama returned to acting in 2000 with a guest role in Hechizo de Amor.

[citation needed] In 2012, Mayra Alejandra was diagnosed with lung cancer and underwent chemotherapy.