[1] Zayid then turned to stand-up and began appearing at New York's top clubs, including Caroline's, Gotham, and Stand Up NY, where she takes on serious topics such as the Israel-Palestine conflict.

In late 2006, Zayid debuted her one-woman show Little American Whore (LAW) at Los Angeles's Comedy Central stage; it was produced and directed by Kathy Najimy.

[7] She also co-hosts the radio show Fann Majnoon (Arabic: فن مجنون) (Crazy Art) with Obeidallah.

[11] Zayid has said repeatedly that she wants to appear on the ABC daytime soap opera General Hospital,[10][12][13] and in June 2019 she debuted in the recurring role of Zahra Amir in the series.

[14][15] Zayid spends three months a year in the Palestinian territories, running an arts program for disabled and orphaned children in refugee camps.