It lies significantly lower in elevation than Guatemala City or Quetzaltenango, as it sits on the coastal plain leading to the Pacific Ocean.

The climate is hotter and more humid than that of the other cities in higher elevations.. During the month of February, an eight-day Carnival Feast takes place in the city, with food, music, parades, and games.

Mazatenango is a major producer of gold, silver, tile, fabric, and furniture.

Mazatenango is home to Guatemala's top division football side CD Suchitepéquez.

The team plays its home fixtures at Estadio Carlos Salazar Hijo in the Santa Cristina neighborhood.